Human AFF4 activation kit by CRISPRa

CAT#: GA109022

AFF4 CRISPRa kit - CRISPR gene activation of human AF4/FMR2 family member 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AFF4
• Locus ID: 27125
• Kit Components:

  GA109022G1, AFF4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109022G2, AFF4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109022G3, AFF4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014423
• Synonyms: AF5Q31; MCEF
• Summary: The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011]