Human TINAG activation kit by CRISPRa

CAT#: GA109093

TINAG CRISPRa kit - CRISPR gene activation of human tubulointerstitial nephritis antigen

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TINAG
• Locus ID: 27283
• Kit Components:

  GA109093G1, TINAG gRNA vector 1 in pCas-Guide-CRISPRa

  GA109093G2, TINAG gRNA vector 2 in pCas-Guide-CRISPRa

  GA109093G3, TINAG gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014464
• Synonyms: TIN-AG
• Summary: This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]