Human Piccolo (PCLO) activation kit by CRISPRa

CAT#: GA109153

PCLO CRISPRa kit - CRISPR gene activation of human piccolo presynaptic cytomatrix protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PCLO
• Locus ID: 27445
• Kit Components:

  GA109153G1, PCLO gRNA vector 1 in pCas-Guide-CRISPRa

  GA109153G2, PCLO gRNA vector 2 in pCas-Guide-CRISPRa

  GA109153G3, PCLO gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014510, NM_033026
• Synonyms: ACZ
• Summary: The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]