Human VPREB3 activation kit by CRISPRa

CAT#: GA109276

VPREB3 CRISPRa kit - CRISPR gene activation of human V-set pre-B cell surrogate light chain 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: VPREB3
• Locus ID: 29802
• Kit Components:

  GA109276G1, VPREB3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109276G2, VPREB3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109276G3, VPREB3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_013378
• Synonyms: 8HS20; N27C7-2
• Summary: The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]