Human KCNIP1 activation kit by CRISPRa

CAT#: GA109390

KCNIP1 CRISPRa kit - CRISPR gene activation of human potassium voltage-gated channel interacting protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNIP1
• Locus ID: 30820
• Kit Components:

  GA109390G1, KCNIP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109390G2, KCNIP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109390G3, KCNIP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001034837, NM_001034838, NM_001278339, NM_001278340, NM_014592
• Synonyms: KCHIP1; VABP
• Summary: This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]