Human Collagen V (COL5A3) activation kit by CRISPRa

CAT#: GA109422

COL5A3 CRISPRa kit - CRISPR gene activation of human collagen type V alpha 3 chain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: COL5A3
• Locus ID: 50509
• Kit Components:

  GA109422G1, COL5A3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109422G2, COL5A3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109422G3, COL5A3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015719
• Synonyms: collagen, type V, alpha 3; OTTHUMP00000195993; pro-(alpha)3(V) collagen
• Summary: This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are thought to be responsible for the symptoms of a subset of patients with Ehlers-Danlos syndrome type III. Messages of several sizes can be detected in northern blots but sequence information cannot confirm the identity of the shorter messages. [provided by RefSeq, Jul 2008]