Human EXOSC1 activation kit by CRISPRa

CAT#: GA109497

EXOSC1 CRISPRa kit - CRISPR gene activation of human exosome component 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EXOSC1
• Locus ID: 51013
• Kit Components:

  GA109497G1, EXOSC1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109497G2, EXOSC1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109497G3, EXOSC1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001318362, NM_001318363, NM_001318364, NM_001318365, NM_001318366, NM_016046, NR_134586, NR_134587, N34159
• Synonyms: CGI-108; CSL4; Csl4p; hCsl4p; p13; SKI4; Ski4p
• Summary: This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2016]