Human Glutaredoxin 2 (GLRX2) activation kit by CRISPRa

CAT#: GA109505

GLRX2 CRISPRa kit - CRISPR gene activation of human glutaredoxin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GLRX2
• Locus ID: 51022
• Kit Components:

  GA109505G1, GLRX2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109505G2, GLRX2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109505G3, GLRX2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001243399, NM_001319291, NM_016066, NM_197962
• Synonyms: CGI-133; GRX2
• Summary: The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. [provided by RefSeq, Aug 2011]