Human CHREBP (MLXIPL) activation kit by CRISPRa

CAT#: GA109550

MLXIPL CRISPRa kit - CRISPR gene activation of human MLX interacting protein like

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MLXIPL
• Locus ID: 51085
• Kit Components:

  GA109550G1, MLXIPL gRNA vector 1 in pCas-Guide-CRISPRa

  GA109550G2, MLXIPL gRNA vector 2 in pCas-Guide-CRISPRa

  GA109550G3, MLXIPL gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_032951, NM_032952, NM_032953, NM_032954, NM_032994, NR_134541
• Synonyms: bHLHd14; CHREBP; MIO; MLX; MONDOB; WBSCR14; WS-bHLH
• Summary: This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]