Human Glycoprotein VI (GP6) activation kit by CRISPRa

CAT#: GA109650

GP6 CRISPRa kit - CRISPR gene activation of human glycoprotein VI platelet

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GP6
• Locus ID: 51206
• Kit Components:

  GA109650G1, GP6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109650G2, GP6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109650G3, GP6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001083899, NM_001256017, NM_016363
• Synonyms: BDPLT11; GPIV; GPVI
• Summary: This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]