Human DACT1 activation kit by CRISPRa

CAT#: GA109753

DACT1 CRISPRa kit - CRISPR gene activation of human dishevelled binding antagonist of beta catenin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DACT1
• Locus ID: 51339
• Kit Components:

  GA109753G1, DACT1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109753G2, DACT1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109753G3, DACT1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001079520, NM_016651, NR_046093, NR_046095
• Synonyms: DAPPER; DAPPER1; DPR1; FRODO; HDPR1; THYEX3
• Summary: The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]