Human ZAK (MAP3K20) activation kit by CRISPRa

CAT#: GA109987

MAP3K20 CRISPRa kit - CRISPR gene activation of human mitogen-activated protein kinase kinase kinase 20

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MAP3K20
• Locus ID: 51776
• Kit Components:

  GA109987G1, MAP3K20 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109987G2, MAP3K20 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109987G3, MAP3K20 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016653, NM_133646
• Synonyms: AZK; MLK7; mlklak; MLT; MLTK; MRK; pk
• Summary: This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]