Human XRN1 activation kit by CRISPRa

CAT#: GA110115

XRN1 CRISPRa kit - CRISPR gene activation of human 5'-3' exoribonuclease 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: XRN1
• Locus ID: 54464
• Kit Components:

  GA110115G1, XRN1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110115G2, XRN1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110115G3, XRN1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001042604, NM_001282857, NM_001282859, NM_019001
• Synonyms: SEP1
• Summary: This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]