Human ING3 activation kit by CRISPRa

CAT#: GA110179

ING3 CRISPRa kit - CRISPR gene activation of human inhibitor of growth family member 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ING3
• Locus ID: 54556
• Kit Components:

  GA110179G1, ING3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110179G2, ING3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110179G3, ING3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_019071, NM_198266, NM_198267
• Synonyms: Eaf4; ING2; MEAF4; p47ING3
• Summary: The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]