Human FBLIM1 activation kit by CRISPRa

CAT#: GA110240

FBLIM1 CRISPRa kit - CRISPR gene activation of human filamin binding LIM protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FBLIM1
• Locus ID: 54751
• Kit Components:

  GA110240G1, FBLIM1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110240G2, FBLIM1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110240G3, FBLIM1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001024215, NM_001024216, NM_017556, NM_001350151
• Synonyms: CAL; FBLP-1; FBLP1
• Summary: This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]