Human FANCL activation kit by CRISPRa

CAT#: GA110531

FANCL CRISPRa kit - CRISPR gene activation of human FA complementation group L

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FANCL
• Locus ID: 55120
• Kit Components:

  GA110531G1, FANCL gRNA vector 1 in pCas-Guide-CRISPRa

  GA110531G2, FANCL gRNA vector 2 in pCas-Guide-CRISPRa

  GA110531G3, FANCL gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001114636, NM_018062, NR_156742
• Synonyms: FAAP43; PHF9; POG
• Summary: This gene encodes a ubiquitin ligase that is a member of the Fanconi anemia complementation group (FANC). Members of this group are related by their assembly into a common nuclear protein complex rather than by sequence similarity. This gene encodes the protein for complementation group L that mediates monoubiquitination of FANCD2 as well as FANCI. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2018]