Human OTUD5 activation kit by CRISPRa

CAT#: GA110808

OTUD5 CRISPRa kit - CRISPR gene activation of human OTU deubiquitinase 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OTUD5
• Locus ID: 55593
• Kit Components:

  GA110808G1, OTUD5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110808G2, OTUD5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110808G3, OTUD5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001136157, NM_001136158, NM_001136159, NM_017602
• Synonyms: DUBA
• Summary: This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]