Human IFT122 activation kit by CRISPRa

CAT#: GA110950

IFT122 CRISPRa kit - CRISPR gene activation of human intraflagellar transport 122

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IFT122
• Locus ID: 55764
• Kit Components:

  GA110950G1, IFT122 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110950G2, IFT122 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110950G3, IFT122 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001280541, NM_001280545, NM_001280546, NM_018262, NM_052985, NM_052989, NM_052990
• Synonyms: CED; CED1; SPG; WDR10; WDR10p; WDR140
• Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Mutations in this gene cause cranioectodermal dysplasia-1. A related pseudogene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]