Human CSGALNACT1 activation kit by CRISPRa

CAT#: GA110972

CSGALNACT1 CRISPRa kit - CRISPR gene activation of human chondroitin sulfate N-acetylgalactosaminyltransferase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CSGALNACT1
• Locus ID: 55790
• Kit Components:

  GA110972G1, CSGALNACT1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110972G2, CSGALNACT1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110972G3, CSGALNACT1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130518, NM_018371, NR_024040, NM_001354475, NM_001354476, NM_001354477, NM_001354480, NM_001354481, NM_001354483, NM_001354484, NM_001354485, NM_001354487, NM_001354488, NM_001354489, NM_001354490, NM_001354491, NM_001354492, NM_001354494, NM_001354495, NM_001354496, NM_001354497, NM_001354498, NM_001354499, NR_148897, NR_148898, NR_148899, NR_148900, NR_148901, NR_148902
• Synonyms: beta4GalNAcT; ChGn; CSGalNAcT-1
• Summary: This gene encodes an enzyme that transfers N-acetylglucosamine (GalNAc) to the core tetrasaccharide linker and to elongating chondroitin sulfate chains in proteoglycans. Knockout of the orthologous mouse gene indicates that the protein is necessary for normal cartilage development and aggrecan metabolism. Mutations in this gene are associated with multiple sclerosis progression, and with mild skeletal dysplasia and joint laxity. [provided by RefSeq, Aug 2017]