Human ERBIN activation kit by CRISPRa

CAT#: GA111058

ERBIN CRISPRa kit - CRISPR gene activation of human erbb2 interacting protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ERBIN
• Locus ID: 55914
• Kit Components:

  GA111058G1, ERBIN gRNA vector 1 in pCas-Guide-CRISPRa

  GA111058G2, ERBIN gRNA vector 2 in pCas-Guide-CRISPRa

  GA111058G3, ERBIN gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001006600, NM_001253697, NM_001253698, NM_001253699, NM_001253701, NM_018695, N67861
• Synonyms: ERBB2IP; HEL-S-78; LAP2
• Summary: This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]