Human DAP13 (NDUFA12) activation kit by CRISPRa

CAT#: GA111074

NDUFA12 CRISPRa kit - CRISPR gene activation of human NADH:ubiquinone oxidoreductase subunit A12

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NDUFA12
• Locus ID: 55967
• Kit Components:

  GA111074G1, NDUFA12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111074G2, NDUFA12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111074G3, NDUFA12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001258338, NM_018838
• Synonyms: B17.2; DAP13
• Summary: This gene encodes a protein which is part of mitochondrial complex 1, part of the oxidative phosphorylation system in mitochondria. Complex 1 transfers electrons to ubiquinone from NADH which establishes a proton gradient for the generation of ATP. Mutations in this gene are associated with Leigh syndrome due to mitochondrial complex 1 deficiency. Pseudogenes of this gene are located on chromosomes 5 and 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]