Human CFC1 activation kit by CRISPRa

CAT#: GA111083

CFC1 CRISPRa kit - CRISPR gene activation of human cripto, FRL-1, cryptic family 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CFC1
• Locus ID: 55997
• Kit Components:

  GA111083G1, CFC1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111083G2, CFC1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111083G3, CFC1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001270420, NM_001270421, NM_032545
• Synonyms: CFC1B; CRYPTIC; DTGA2; HTX2
• Summary: This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development, including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]