Human CTPS2 activation kit by CRISPRa

CAT#: GA111188

CTPS2 CRISPRa kit - CRISPR gene activation of human CTP synthase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CTPS2
• Locus ID: 56474
• Kit Components:

  GA111188G1, CTPS2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111188G2, CTPS2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111188G3, CTPS2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001144002, NM_019857, NM_175859
• Synonyms: DKFZp686C17207; FLJ43358; MGC32997
• Summary: The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]