Human KCNQ5 activation kit by CRISPRa

CAT#: GA111192

KCNQ5 CRISPRa kit - CRISPR gene activation of human potassium voltage-gated channel subfamily Q member 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNQ5
• Locus ID: 56479
• Kit Components:

  GA111192G1, KCNQ5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111192G2, KCNQ5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111192G3, KCNQ5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001160130, NM_001160132, NM_001160133, NM_001160134, NM_019842
• Synonyms: Kv7.5
• Summary: This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]