Human CDC42SE2 activation kit by CRISPRa

CAT#: GA111322

CDC42SE2 CRISPRa kit - CRISPR gene activation of human CDC42 small effector 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDC42SE2
• Locus ID: 56990
• Kit Components:

  GA111322G1, CDC42SE2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111322G2, CDC42SE2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111322G3, CDC42SE2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001038702, NM_020240
• Synonyms: SPEC2
• Summary: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. [UniProtKB/Swiss-Prot Function]