Human Pellino 1 (PELI1) activation kit by CRISPRa

CAT#: GA111419

PELI1 CRISPRa kit - CRISPR gene activation of human pellino E3 ubiquitin protein ligase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PELI1
• Locus ID: 57162
• Kit Components:

  GA111419G1, PELI1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111419G2, PELI1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111419G3, PELI1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020651
• Synonyms: DKFZp686C18116; MGC50990
• Summary: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. [UniProtKB/Swiss-Prot Function]