Human CLTRN activation kit by CRISPRa

CAT#: GA111477

CLTRN CRISPRa kit - CRISPR gene activation of human collectrin, amino acid transport regulator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CLTRN
• Locus ID: 57393
• Kit Components:

  GA111477G1, CLTRN gRNA vector 1 in pCas-Guide-CRISPRa

  GA111477G2, CLTRN gRNA vector 2 in pCas-Guide-CRISPRa

  GA111477G3, CLTRN gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020665
• Synonyms: NX-17; NX17
• Summary: This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013]