Human Raptor (RPTOR) activation kit by CRISPRa

CAT#: GA111556

RPTOR CRISPRa kit - CRISPR gene activation of human regulatory associated protein of MTOR complex 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RPTOR
• Locus ID: 57521
• Kit Components:

  GA111556G1, RPTOR gRNA vector 1 in pCas-Guide-CRISPRa

  GA111556G2, RPTOR gRNA vector 2 in pCas-Guide-CRISPRa

  GA111556G3, RPTOR gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001163034, NM_020761
• Synonyms: KOG1; Mip1
• Summary: This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]