Human KCNT1 activation kit by CRISPRa

CAT#: GA111608

KCNT1 CRISPRa kit - CRISPR gene activation of human potassium sodium-activated channel subfamily T member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNT1
• Locus ID: 57582
• Kit Components:

  GA111608G1, KCNT1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111608G2, KCNT1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111608G3, KCNT1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001272003, NM_020822
• Synonyms: bA100C15.2; EIEE14; ENFL5; KCa4.1; SLACK; Slo2.2
• Summary: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]