Human DENND1A activation kit by CRISPRa

CAT#: GA111700

DENND1A CRISPRa kit - CRISPR gene activation of human DENN domain containing 1A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DENND1A
• Locus ID: 57706
• Kit Components:

  GA111700G1, DENND1A gRNA vector 1 in pCas-Guide-CRISPRa

  GA111700G2, DENND1A gRNA vector 2 in pCas-Guide-CRISPRa

  GA111700G3, DENND1A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020946, NM_024820, NM_001352964, NM_001352965, NM_001352966, NM_001352967, NM_001352968, NR_148208
• Synonyms: FAM31A; KIAA1608
• Summary: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]). [supplied by OMIM, Nov 2010]