Human G6PC2 activation kit by CRISPRa

CAT#: GA111735

G6PC2 CRISPRa kit - CRISPR gene activation of human glucose-6-phosphatase catalytic subunit 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: G6PC2
• Locus ID: 57818
• Kit Components:

  GA111735G1, G6PC2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111735G2, G6PC2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111735G3, G6PC2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001081686, NM_021176
• Synonyms: IGRP
• Summary: This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]