Human PAPP A2 (PAPPA2) activation kit by CRISPRa

CAT#: GA111880

PAPPA2 CRISPRa kit - CRISPR gene activation of human pappalysin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PAPPA2
• Locus ID: 60676
• Kit Components:

  GA111880G1, PAPPA2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111880G2, PAPPA2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111880G3, PAPPA2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020318, NM_021936
• Synonyms: PAPP-A2; PAPP-E; PAPPE; PLAC3
• Summary: This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]