Human XYLT2 activation kit by CRISPRa

CAT#: GA111994

XYLT2 CRISPRa kit - CRISPR gene activation of human xylosyltransferase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: XYLT2
• Locus ID: 64132
• Kit Components:

  GA111994G1, XYLT2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111994G2, XYLT2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111994G3, XYLT2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_022167, NR_110010
• Synonyms: PXYLT2; SOS; XT-II; XT2; xylT-II
• Summary: The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]