Human Artemis (DCLRE1C) activation kit by CRISPRa

CAT#: GA112072

DCLRE1C CRISPRa kit - CRISPR gene activation of human DNA cross-link repair 1C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DCLRE1C
• Locus ID: 64421
• Kit Components:

  GA112072G1, DCLRE1C gRNA vector 1 in pCas-Guide-CRISPRa

  GA112072G2, DCLRE1C gRNA vector 2 in pCas-Guide-CRISPRa

  GA112072G3, DCLRE1C gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001033855, NM_001033857, NM_001033858, NM_001289076, NM_001289077, NM_001289078, NM_001289079, NM_022487, NR_110297, NM_001350965, NM_001350966, NM_001350967, NR_146960, NR_146961, NR_146962
• Synonyms: A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C
• Summary: This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]