Human CENPM activation kit by CRISPRa

CAT#: GA112314

CENPM CRISPRa kit - CRISPR gene activation of human centromere protein M

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CENPM
• Locus ID: 79019
• Kit Components:

  GA112314G1, CENPM gRNA vector 1 in pCas-Guide-CRISPRa

  GA112314G2, CENPM gRNA vector 2 in pCas-Guide-CRISPRa

  GA112314G3, CENPM gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001002876, NM_001110215, NM_001304370, NM_001304371, NM_001304372, NM_001304373, NM_024053
• Synonyms: C22orf18; CENP-M; PANE1
• Summary: The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]