Human CARS2 activation kit by CRISPRa

CAT#: GA112473

CARS2 CRISPRa kit - CRISPR gene activation of human cysteinyl-tRNA synthetase 2, mitochondrial

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CARS2
• Locus ID: 79587
• Kit Components:

  GA112473G1, CARS2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112473G2, CARS2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112473G3, CARS2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_024537, NM_001352252, NM_001352253, NR_147941, NR_147942
• Synonyms: COXPD27; cysRS
• Summary: This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of cysteine to tRNA molecules. A splice-site mutation in this gene has been associated with a novel progressive myoclonic epilepsy disease with similar symptoms to MERRF syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017]