Human SEMA6D activation kit by CRISPRa

CAT#: GA112801

SEMA6D CRISPRa kit - CRISPR gene activation of human semaphorin 6D

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SEMA6D
• Locus ID: 80031
• Kit Components:

  GA112801G1, SEMA6D gRNA vector 1 in pCas-Guide-CRISPRa

  GA112801G2, SEMA6D gRNA vector 2 in pCas-Guide-CRISPRa

  GA112801G3, SEMA6D gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001198999, NM_020858, NM_024966, NM_153616, NM_153617, NM_153618, NM_153619, NM_001358351, NM_001358352
• Synonyms: FLJ11598; KIAA1479
• Summary: Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]