Human PIF1 activation kit by CRISPRa

CAT#: GA112821

PIF1 CRISPRa kit - CRISPR gene activation of human PIF1 5'-to-3' DNA helicase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PIF1
• Locus ID: 80119
• Kit Components:

  GA112821G1, PIF1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112821G2, PIF1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112821G3, PIF1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286496, NM_001286497, NM_001286499, NM_025049
• Synonyms: C15orf20; PIF
• Summary: This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013]