Human RNF34 activation kit by CRISPRa

CAT#: GA112860

RNF34 CRISPRa kit - CRISPR gene activation of human ring finger protein 34

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RNF34
• Locus ID: 80196
• Kit Components:

  GA112860G1, RNF34 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112860G2, RNF34 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112860G3, RNF34 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256858, NM_025126, NM_194271
• Synonyms: CARP-1; CARP1; hRFI; RFI; RIF; RIFF
• Summary: The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]