Human TXNDC5 activation kit by CRISPRa

CAT#: GA113071

TXNDC5 CRISPRa kit - CRISPR gene activation of human thioredoxin domain containing 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TXNDC5
• Locus ID: 81567
• Kit Components:

  GA113071G1, TXNDC5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113071G2, TXNDC5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113071G3, TXNDC5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145549, NM_022085, NM_030810
• Synonyms: ENDOPDI; ERP46; HCC-2; PDIA15; STRF8; UNQ364
• Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]