Human DOCK8 activation kit by CRISPRa

CAT#: GA113114

DOCK8 CRISPRa kit - CRISPR gene activation of human dedicator of cytokinesis 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DOCK8
• Locus ID: 81704
• Kit Components:

  GA113114G1, DOCK8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113114G2, DOCK8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113114G3, DOCK8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001190458, NM_001193536, NM_203447
• Synonyms: HEL-205; MRD2; ZIR8
• Summary: This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]