Human SETDB2 activation kit by CRISPRa

CAT#: GA113273

SETDB2 CRISPRa kit - CRISPR gene activation of human SET domain bifurcated histone lysine methyltransferase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SETDB2
• Locus ID: 83852
• Kit Components:

  GA113273G1, SETDB2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113273G2, SETDB2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113273G3, SETDB2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001160308, NM_031915, NM_001320699
• Synonyms: C13orf4; CLLD8; CLLL8; KMT1F
• Summary: This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]