Human KIRREL 3 (KIRREL3) activation kit by CRISPRa

CAT#: GA113611

KIRREL3 CRISPRa kit - CRISPR gene activation of human kirre like nephrin family adhesion molecule 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KIRREL3
• Locus ID: 84623
• Kit Components:

  GA113611G1, KIRREL3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113611G2, KIRREL3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113611G3, KIRREL3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001161707, NM_001301097, NM_032531
• Synonyms: KIRRE; MRD4; NEPH2; PRO4502
• Summary: The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. The protein encoded by this gene is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. Mutations in this gene are associated with several neurological and cognitive disorders. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]