Human PLCZ1 activation kit by CRISPRa

CAT#: GA113946

PLCZ1 CRISPRa kit - CRISPR gene activation of human phospholipase C zeta 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PLCZ1
• Locus ID: 89869
• Kit Components:

  GA113946G1, PLCZ1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113946G2, PLCZ1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113946G3, PLCZ1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_033123, NR_073075, NM_001330769, NM_001330774
• Synonyms: NYD-SP27; PLC-zeta-1; PLCzeta
• Summary: The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]