Human MYLK3 activation kit by CRISPRa

CAT#: GA114157

MYLK3 CRISPRa kit - CRISPR gene activation of human myosin light chain kinase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MYLK3
• Locus ID: 91807
• Kit Components:

  GA114157G1, MYLK3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114157G2, MYLK3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114157G3, MYLK3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001308301, NM_182493
• Synonyms: caMLCK; MLCK; MLCK2
• Summary: Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]). [supplied by OMIM, Jul 2008]