Human LYK5 (STRADA) activation kit by CRISPRa

CAT#: GA114205

STRADA CRISPRa kit - CRISPR gene activation of human STE20 related adaptor alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: STRADA
• Locus ID: 92335
• Kit Components:

  GA114205G1, STRADA gRNA vector 1 in pCas-Guide-CRISPRa

  GA114205G2, STRADA gRNA vector 2 in pCas-Guide-CRISPRa

  GA114205G3, STRADA gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001003786, NM_001003787, NM_001003788, NM_001165969, NM_001165970, NM_153335, NM_001363786, NM_001363787, NM_001363789, NM_001363790, NM_001363791, NM_001363788, NR_156741
• Synonyms: LYK5; NY-BR-96; PMSE; Stlk; STRAD
• Summary: The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]