Human PGAP3 activation kit by CRISPRa

CAT#: GA114273

PGAP3 CRISPRa kit - CRISPR gene activation of human post-GPI attachment to proteins 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PGAP3
• Locus ID: 93210
• Kit Components:

  GA114273G1, PGAP3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114273G2, PGAP3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114273G3, PGAP3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001291726, NM_001291728, NM_001291730, NM_001291732, NM_001291733, NM_033419
• Synonyms: AGLA546; CAB2; hCOS16; PERLD1; PP1498
• Summary: This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause an autosomal recessive form of neurologic hyperphosphatasia with cognitive disability (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]