Human PLC delta 3 (PLCD3) activation kit by CRISPRa

CAT#: GA114384

PLCD3 CRISPRa kit - CRISPR gene activation of human phospholipase C delta 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PLCD3
• Locus ID: 113026
• Kit Components:

  GA114384G1, PLCD3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114384G2, PLCD3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114384G3, PLCD3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_133373
• Synonyms: PLC-delta-3
• Summary: This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]