Human GPCR TGR7 (MRGPRD) activation kit by CRISPRa

CAT#: GA114601

MRGPRD CRISPRa kit - CRISPR gene activation of human MAS related GPR family member D

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MRGPRD
• Locus ID: 116512
• Kit Components:

  GA114601G1, MRGPRD gRNA vector 1 in pCas-Guide-CRISPRa

  GA114601G2, MRGPRD gRNA vector 2 in pCas-Guide-CRISPRa

  GA114601G3, MRGPRD gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_198923
• Synonyms: MRGD; TGR7
• Summary: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i). [UniProtKB/Swiss-Prot Function]