Human CENTD1 (ARAP2) activation kit by CRISPRa

CAT#: GA114619

ARAP2 CRISPRa kit - CRISPR gene activation of human ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARAP2
• Locus ID: 116984
• Kit Components:

  GA114619G1, ARAP2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114619G2, ARAP2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114619G3, ARAP2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015230, NM_139182, NR_146893, NR_146894
• Synonyms: CENTD1; PARX
• Summary: The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]